张会;石绵绵;李伟;吴水生;王明兹;郑永标;

• 1:福建师范大学生命科学学院
• 2:福建中医药大学药学院
• 3:福建师范大学工业微生物教育部工程研究中心
• 4:福建师范大学细胞逆境响应与代谢调控福建省高校重点实验室

摘要(Abstract)：

研究闽浙马尾杉内生真菌炭团菌Hypoxylon investiens NX9的次级代谢产物及其对乙酰胆碱酯酶的抑制活性.将菌株H.investiens NX9进行液体发酵20 L,用乙酸乙酯萃取得到4.448 g有机粗提物,采用色谱技术从中分离到6个萘酮衍生物和1个倍半萜类化合物,根据核磁波谱数据分别鉴定为(S)-regiolone (1)、3,4-dihydro-3,6,8-trihydroxy-3-methyl-naphthalenone (2)、xylarenone (3)、(3S,4R)-3,4-dihydro-3,4,5-trihydroxynaphthalen-1(2H)-one (4)、4,5-dihydroxy--tetralone (5)、3,4-dihydro-3,4,8-trihydr-oxy-1-naphthalenone (6)和xylaranol B (7).乙酰胆碱酯酶抑制实验显示化合物3具有一定的活性,ρ_(IC50)为5.23 mg·mL~(-1).研究表明以药用植物的内生菌为资源,是发现活性药物的一条有效途径.

关键词(KeyWords)： 马尾杉;炭团菌;乙酰胆碱酯酶

Abstract:

Keywords:

基金项目(Foundation): 福建省自然科学基金资助项目(2016J01353);; 福建省科技厅社会发展引导性(重点)项目(2016Y0030);; 福建师范大学化学免疫学创新团队项目(IRT1703)

作者(Author): 张会;石绵绵;李伟;吴水生;王明兹;郑永标;

Email:

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