江剑平;付艳;胡粉娟;

• 1:福建师范大学生命科学学院福建省发育和神经生物学重点实验室
• 2:大秦家畜牧兽医站

摘要(Abstract)：

通过观察腰段脊髓背角c-Fos阳性神经元数量变化,探讨鞘内间隔联合应用牛肾上腺髓质8-22肽(bovine adrenal medulla 8-22,BAM8-22)在福尔马林引起的持续性痛中对吗啡耐受的影响.结果显示,连续6 d应用吗啡导致耐受(吗啡耐受组)后,福尔马林诱发的c-Fos阳性神经元数量明显增加,与吗啡组相比,其脊髓Ⅰ-Ⅱ、Ⅲ-Ⅳ和Ⅴ-Ⅵ层c-Fos阳性神经元分别增加了164.9%、131.5%和125.3%(P<0.05⁰.01);但隔天给予BAM8-22(吗啡+BAM8-22组)则能明显增强慢性吗啡抑制c-Fos阳性神经元的表达,与吗啡耐受组相比,其脊髓Ⅰ-Ⅱ和Ⅴ-Ⅵ层c-Fos阳性神经元数量分别下降了66.6%和48.8%(P<0.050.01);但隔天给予BAM8-22(吗啡+BAM8-22组)则能明显增强慢性吗啡抑制c-Fos阳性神经元的表达,与吗啡耐受组相比,其脊髓Ⅰ-Ⅱ和Ⅴ-Ⅵ层c-Fos阳性神经元数量分别下降了66.6%和48.8%(P<0.05⁰.01).在福尔马林引起的持续性痛中,BAM8-22延缓吗啡耐受是通过抑制脊髓背角伤害性神经元的活性来实现的.

关键词(KeyWords)： 牛肾上腺髓质8-22肽(BAM8-22);吗啡耐受;持续性痛;福尔马林实验;c-Fos阳性神经元

Abstract:

Keywords:

基金项目(Foundation): 福建省自然科学基金资助项目(2014J01305);; 福建省教育厅重点项目(JA14072)

作者(Authors): 江剑平;付艳;胡粉娟;

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