黄浩;丁明敏;陈雅娟;

• 1:福建师范大学生命科学学院

摘要(Abstract)：

建立福尔马林疼痛模型,研究不同产地或不同生产批次福尔马林试剂对大鼠炎性痛诱导的效果,并以Dubuisson评分方法进行记录比较.结果表明,国产组第二时相疼痛时间明显短于进口组,二者之间存在极显著差异(p<0.01).不同生产批次的福尔马林试剂对大鼠的炎性痛诱导效果无显著差异.建议在经济条件允许的情况下使用进口封装的福尔马林制作疼痛模型,同一产家的福尔马林试剂在12个月内可以安全使用.

关键词(KeyWords)： 福尔马林疼痛模型;持续性疼痛;疼痛反应行为

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(30470565);; 福建省科技厅重点项目(2006F6001)

作者(Authors): 黄浩;丁明敏;陈雅娟;

参考文献(References)：

• [1]Dubuisson D,Dennis S G.The formalin test:a quantitative study of the analgesic effects of morphine,meperidine,and brain stem stimulation in rats and cats[J].Pain,1977,4:161-174.
• [2]Wheeler-aceto H,Porreca F,Cowan A.The rat paw formalin in comparison of noxious agents[J].Pain,1990,40:229-238.
• [3]Malmberg A B,Yaksh T L.Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on theformalin test in the rat[J].J Pharmacol Exp Ther,1992,263:136-146.
• [4]Abbott F V,Fyanklin K B J,Westbrook R F,et al.The formalin test:scoring properties of the first and secondphases of the pain response in rats[J].Pain,1995,60:91-102.
• [5]Gaumond I,Arsenault P,Marchand S.The role of sex hormones on formalin-induced nociceptive responses[J].Brain Res,2002,958:139-145.
• [6]Megumi Kaneko,Donna L,Hammond.Role of spinalγ-aminobutyric acid receptors in formalin-induced nociceptionin the rat[J].J Pharmacol Exp Ther,1997,282:928-938.
• [7]Aloisi A M,Poroo C A,Cavazzuti M,et al.“Mirror pain”in the formalin test:behavioral and 2-deoxyglucosestudies[J].Pain,1993,55:267-273.