丘脑底核-苍白球外侧-脚桥核网络的振荡动力学分析Analyses of Oscillation Dynamics in a Subthalamic Nucleus-External Globus Pallidus-Pedunculopontine Nucleus Network
陈国泰;郑艳红;
摘要(Abstract)：
基底神经节(BG)是大脑深部一系列神经核团所构成的功能整体，参与精巧运动的形成.BG中丘脑底核(STN)和苍白球(GP)的异常同步振荡被认为与帕金森病(PD)有关.建立丘脑底核-苍白球外侧-脚桥核(STN-GPe-PPN)模型，基于稳定性理论给出了模型产生振荡的稳定性条件，探讨PPN和STN之间的耦合强度对STN-GPe振荡的影响，并分析GPe与STN之间的传输时滞对STN振荡的影响.数值模拟结果表明，丘脑底核受到脚桥核相互之间较强的促进作用和苍白球外侧较大的传输时滞时，丘脑底核会产生更高振幅的振荡.
关键词(KeyWords)： 帕金森病;神经元网络;脚桥核;稳定条件;振荡
基金项目(Foundation): 国家自然科学基金面上项目(11672074)
作者(Authors): 陈国泰;郑艳红;
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