房乾;陈登龙;姚清华;李敏;

• 1:福建师范大学生命科学学院
• 2:福建师范大学生命科学学院
• 3:福建师范大学生命科学学院
• 4:福建师范大学生命科学学院 福建福州350108

摘要(Abstract)：

综述了静电纺丝的基本原理和过程参数,重点描述了静电纺丝及同轴共纺技术在组织工程支架材料领域的应用,最后对电纺技术在组织工程支架材料领域应用中存在的问题和面临的挑战进行了讨论.

关键词(KeyWords)： 静电纺丝;支架材料;组织工程;同轴共纺

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(30570956);; 福建省发改委基金资助项目(2006-781);; 福建省自然科学基金资助项目(E0510015)

作者(Authors): 房乾;陈登龙;姚清华;李敏;

参考文献(References)：

• [1]Formhals A.Process and apparatus for preparing artificial threads:US,1 975 504[P].1934-10-02[2007-05-10].
• [2]Kim H W,Lee H H,Knowles J C.Electrospinning biomedical nanocomposite fibers of hydroxyapatie/poly(lacticacid)for bone regeneration[J].Journal of Biomedical Materials Research,2006,79(3):643-649.
• [3]Li D P,Margaret W,Frey.Electrospun polylactic acid nanofiber membranes as substrates for biosensorassemblies[J].Journal of Membrane Science,2006,279(1/2):354-363.
• [4]Tan S H,Inai R,Kotaki M,et al.Systematic parameter study for ultra-fine fiber fabrication via electrospinning[J].Polymer,2005,46(16):6128-6134.
• [5]Fong H,Reneker D H.Elastomeric nanofibers of styrene-butadiene-styrene triblockcopolymer[J].J Polym Sci:Part B Polym Phys,1999,37(24):3488-3493.
• [6]Zussman E,Yarin A L,Weihs D.A micro-aerodynamic decelerator based on permeable surfaces of nanofiber mats[J].Experiments in Fluids,2002,33:315-320.
• [7]Doshi J,Reneker D H.Electrospinning process and applications of electrospun fibers[J].J Electrostatics,1995,35(2/3):151-160.
• [8]Boudriot U,Dersch R,Greiner A,et al.Electrospinning Approaches toward scaffold engineering-a brief overview[J].Artificial organs,2006,30(10):785-792.
• [9]Yang F,Murugan R,Wang S,et al.Electrospinning of nano/micro scale poly(L-lactic acid)aligned fibers andtheir potential in neural tissue engineering[J].Biomaterials,2005,26(15):2603-2610.
• [10]Kang X,Xie Y,Powell H M,et al.Adipogenesis of murine embryonic stem cells in a three-dimensional culturesystem using electrospun polymer scaffolds[J].Biomaterials,2007,28(3):450-458.
• [11]Chen Z G,Mo X M,Qing F L.Electrospinning of collagen-chitosan complex[J].Materials Letters,2007,61(16):3490-3494.
• [12]Zhong S P,Teo W E,Zhu X,et al.Development of a novel collagen-GAG nanofibrous scaffold via electrospinning[J].Materials Science and Engineering C,2007,27(2):262-266.
• [13]Li M Y,Mark J,Mondrinos,et al.Electrospun protein fibers as matrices for tissue engineering[J].Biomaterials,2005,26(30):5999-6008.
• [14]Duan B,Yuan X Y,Zhu Yi,et al.A nanofibrous composite membrane of PLGA-chitosan/PVA prepared byelectrospinning[J].European Polymer Journal,2006,42(9):2013-2022.
• [15]Li M Y,Mark J,Mondrinos,et al.Co-electrospun poly(lactide-co-glycolide),gelatin,and elastin blends fortissue engineering scaffolds[J].Journal of Biomedical Materials Research,2006,79(4):963-973.
• [16]Chen Denglong,Li Min,Huan Xi.Electrospinning and morphology of recombinant spider silk proteincanofibers[C]∥第四届东亚高分子会议论文.天津:南开大学,2006.
• [17]Townsend-Nicholson A,Jayasinghe S N.Cell electrospinning:a unique biotechnique for encapsulating livingorganisms for generating active biological microthreads/scaffolds[J].Biomacromolecules,2006,7(12):3364-3369.
• [18]Jiang H L,Hu Y Q,Zhao P C,et al.Modulation of protein release from biodegradable core-shell structuredfibers prepared by coaxial electrospinning[J].Journal of Biomedical Materials Research Part B:AppliedBiomaterials,2006,79(1):50-57.