李硕;毛凤;师瑶;王阳;石炜;

• 1:华中农业大学理学院

摘要(Abstract)：

以金属催化的偶联反应为核心,发现了一种新的合成四炔的方法,首先从甲基丁炔醇出发,得到溴代甲基丁炔醇后,和末端炔烃发生Cadiot-Chodkiewicz偶联反应,得到共轭二炔.共轭二炔在碱性环境下脱去丙酮保护生成末端二炔烃后,在Ni和Cu共催化条件下发生Glaser-Hay氧化偶联反应,得到共轭四炔.该方法避免了贵金属催化剂的使用,反应条件温和,原料成本较低,产物易分离.

关键词(KeyWords)： 共轭四炔;Cadiot-Chodkiewicz偶联反应;甲基丁炔醇;镍催化

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(21202050);; 湖北省自然科学基金资助项目(2014CFB930)

作者(Authors): 李硕;毛凤;师瑶;王阳;石炜;

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